Vermont

UVM Flu Research: Accidental Discovery Could Transform Treatments

Proteins in the two most common types of flu virus enable them to take very different paths to entering human lungs, a finding that could lead to more directed antiviral treatments. Read the story on VTDigger here: One UVM lab’s…

Published

3 months ago

June 7, 2026

Randy Breland, Managing Editor

UVM Lab's Accidental Discovery Could Transform Flu Treatments — UVM flu research

Last updated: September 1, 2026

Key points

UVM researchers discovered how H3N2 flu virus infects lung cells differently than H1N1.
The role of the Rab11B protein in viral entry could lead to better antiviral treatments.
Flu remains a critical public health concern in Vermont, with numerous outbreaks reported last winter.

MONTPELIER, Vt. NewsWK — A recent discovery by a University of Vermont (UVM) lab may reshape our understanding of how the flu virus infects humans, which could lead to improved prevention strategies. This finding is particularly relevant for local residents, as Vermont continues to grapple with flu outbreaks, especially during the winter months.

Larner College of Medicine Flu Research Details Breakthrough

Emily Bruce, an assistant professor of microbiology and molecular genetics at UVM’s Larner College of Medicine, led the research that culminated in a paper published in the Journal of Virology. The lab originally focused on the behavior of specific proteins in two common flu viruses, H1N1 and H3N2, but stumbled upon crucial differences in how these viruses infect human lungs.

Key Findings in H3N2 Virus Discovery

The H3N2 virus relies on a protein called Rab11B to penetrate human lung cells, while H1N1 does not.
Previous beliefs suggested that sialic acid was the primary binding point for influenza viruses, but the absence of Rab11B prevented H3N2 from entering cells even in the presence of sialic acid.
This new understanding could guide more targeted antiviral research, as current antiviral options are limited.

Community Impact

Emily Mosites, an epidemiologist for the Vermont Health Department, highlighted the importance of this research, stating, “This new molecular research gives us further insight into how these infections occur.” She noted that flu remains a significant public health issue in Vermont, with 83 outbreaks reported in various facilities last winter.

What’s Next for Vermont Flu Treatments?

As researchers delve deeper into the implications of these findings, there is hope that more effective antiviral treatments could emerge, potentially easing the burden of flu seasons in our community.

Based on reporting originally published by VTDigger. Read the original story.